These are older drugs which are rather non-specific in their action.
Members of this class of drugs may also be used for their side effects, including sedation and antiemesis (prevention of nausea and vomiting). They have no effect on rate of histamine release, nor do they inactivate histamine.
By inhibiting the activity of histamine, they can reduce capillary fragility, which produces the erythema, or redness, associated with allergic reactions.
More particularly, compositions for administration at bedtime containing a sedating antihistamine or other sedating compound in immediate release form and a non-sedating antihistamine in delayed-release form are described.
Alternatively, a composition, for administrating upon awakening, containing a non-sedating antihistamine in immediate release form, and a sedating antihistamine or other sedative in delayed-release form is described.
Compositions containing both a sedative compound and a non-sedative antihistamine are provided.
More particularly, compositions for administration at bedtime containing a sedating antihistamine or other sedating compound in immediate release form and a non-sedating antihistamine in delayed-release form...First-generation antihistamines are considered safe to use during pregnancy.Examples of first-generation antihistamines are brompheniramine, chlorpheniramine, dimenhydrinate, diphenhydramine, doxylamine, hydroxyzine, and pheniramine.wherein the sedating antihistamine is selected from the group consisting of brompheniramine, chiorpheniramine, debrompheniramine, dexchlorpheniramine, carbinoxamine, clemastine, diphenhydramine, pyrilamine, tripelennamine, tripolidine, methdilazine, bromodiphenhydramine, promethazine, azatadine, cyproheptadine, diphenylpyraline, doxylamine, trimeprazine, phenindamine, ketotifen, hydroxyzine, tazifylline, temelastine, meclizine, acrivastine, setastine, oxatomide, mequitazine, levocabastine, lodoxamide, AHR 11325, phenindamine, azelastine, and ebastine, or a pharmaceutically acceptable salt thereof. Antihistamines, normally classified as 1 receptor antagonists, are used for the prophylaxis and relief of symptoms of hypersensitivity reactions.wherein the non-sedating antihistamine is selected from the group consisting of fexofenadine, loratadine, descarboethoxy loratadine, astemizole, norastemizole, desmethylastemizole, cetirizine, acrivastine, and temelastine, or a pharmaceutically acceptable salt thereof. The term “antihistamine” is generally applied to Histamine 1 receptor antagonists.Methods of inhibiting the release of histamines by administration of the compositions to a mammalian subject are also provided. 6,827,946, entitled “Compositions Containing Both Sedative and Non-Sedative Antihistamines” by Mark Hirsh, Jane Hirsh, and Whe-Yong Lo.